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沈雷

来源:英雄联盟比赛投注网站 发布时间:2019.01.16 14:49
  


沈雷  简介

     出生年月:19832

学位: 博士      职称: 教授,博士生导师

Emailleishen@whut.edu.cn

 

教育经历:

2003-2008,中国科学技术大学 & University of Toronto,博士(联培),导师:吴奇 院士 & Prof. Mitchell A. Winnik

1999-2003,中国科学技术大学,化学物理系,本科

 

研究经历:

2017-今,英雄联盟比赛投注网站,英雄联盟比赛投注网站,教授

2013-2016,华中科技大学,化学与化工学院,副教授

2012-2013,美国 Columbia University,化学系,助理研究员

2009-2012,美国 The University of Texas at Austin & University of Minnesota,博士后,合作导师:Prof. Xiaoyang Zhu & Prof. Timothy Lodge

2008-2009,瑞士University of Geneva,博士后,合作导师:Prof. Michal Borkovec

 

研究领域:

课题组聚焦大分子表界面的基础研究,利用化学、物理、高分子物理、生物化学等多学科交叉手段解决与大分子表界面相关的重要科学问题,设计功能界面材料。

招收研究生方向:物理化学、材料、高分子、无机、有机化学等。

近年来培养的研究生获国家一等奖学金、学校一等奖学金、三好学生和优秀毕业生称号。

欢迎喜欢化学的你加入课题组!

 

主要科研项目:

1.     国家自然科学基金面上项目,糖脂双层膜界面在阿尔茨海默病Abeta肽聚集中的作用研究,2016-2019,主持;

2.     国家自然科学基金青年项目,流感病毒HA蛋白质与糖的多价相互作用研究,2015-2017,主持;

3.     英雄联盟比赛投注网站"15551"青年拔尖人才,2019-2024

 

代表性论文:

在专业核心期刊上发表论文50余篇,包括化学领域内顶尖期刊J. Am. Chem. Soc.Chem. Commun., MacromoleculesACS Macro Lett., Langmuir等,他引1250余次,多次被审稿人和国际同行亮点评述,并在国际权威胶体界面化学综述期刊Adv. Colloid Interface Sci.撰写综述。

 

1.     (Invited Cover work) M. Tian, Lei Shen*, Self-coiling of single-stranded protofibrils into rings: A pathway of Alzheimer’s beta-peptide amyloidosis on lipid membranes. ACS Macro Lett. 2020, 9, 813.

2.     J. Liu, M. Tian, Lei Shen*, Surface effects on the degree of twist in amyloid fibril structures. Chem. Commun. 2020, 56, 3147.

3.     J. Liu, M. Tian, Lei Shen*, Nanopatterned polymer surface modulates twist polymorphism in a single amyloid fibril. Macro. Rapid Commun. 2020, 41, 1900619.

4.     (Invited cover work) S. Cai, J. Liu, M. Tian, K Wang, Lei Shen*, Diffusion dynamics of a single collapsed homopolymer globule at solid-liquid interface. Soft Matter, 2020, 16, 2431.

5.     S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, 55, 13725.

6.     (Invited cover work) P. Li, Y. Shen, L. Wang, W. Lu, W. Li, K. Chen, Y. Zhou, Lei Shen*, F. Wei*, W. Zheng, The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter, 2019, 15, 4445.

7.     J. Lin, K. Wang, X. Xia, Lei Shen*. Quantification of Multivalency in Protein Oligomer Coated Nanoparticles Targeting Dynamic Membrane Glycan Receptors. Langmuir, 2018, 34, 8415.

8.     M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir, 2018, 34, 8408.

9.     K. Wang, Y. Chen, X. Gong, J. Xia, J. Zhao*, Lei Shen*. A mobile precursor determines protein resistance on nanostructured surfaces. Phys. Chem. Chem, Phys., 2018, 20, 12527.

10.  K. Shezad, K. Zhang, M. Hussain, H. Dong, C. He, X. Gong, X. Xie, J. Zhu*, Lei Shen*. Surface roughness modulated diffusion and fibrillation of amyloid-beta peptide. Langmuir, 2016, 32, 8238.

11.  Lei Shen, Y. Wang, C. Lin, H. Liu*, A. Guo*, X. Y. Zhu*. Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors. ACS Chem. Biol., 2014, 9, 1877.

12.  Lei Shen, T. Adachi, D. Vanden Bout, X. Y. Zhu*. A mobile precursor determines amyloid-beta peptide fibril formation at interfaces. J. Am. Chem. Soc., 2012, 134, 14172.

 

获奖与荣誉:

湖北省楚天学者计划(楚天学子)2015年,高分子化学与物理

 

Prof. Lei Shen

Tel: +86-15926376089

Email: leishen@whut.edu.cn

 

Education

2003   B.Sc.  University of Science & Technology of China

2008   Ph.D.  University of Science & Technology of China

 

Position

Since 2017    Professor, Wuhan University of Technology

2014-2016    Associate Professor, Huazhong University of Science and Technology

2012-2013    Associate Research Scientist, Columbia University, USA

2009-2012    Research Associate, The University of Texas at Austin, USA

2009-2009    Research Associate, University of Minnesota, USA

2008-2009    Research Associate, University of Geneva, Switzerland

 

Research Interests

Our research interests focus on macromolecules at surfaces and bio-interface phenomena, including:

1.    nucleation and fiber formation of neuro-degenerative diseases related proteins and peptides at surfaces;

2.    molecular characteristic properties of polymers at surfaces;

3.    multivalent interactions at bio-interfaces;

4.    design, synthesis and modification of interfacial materials

 

Representative Publications

1.    (Invited cover work) M. Tian, Lei Shen*, Self-coiling of single-stranded protofibrils into rings: A pathway of Alzheimer’s beta-peptide amyloidosis on lipid membranes. ACS Macro Lett. 2020, 9, 813.

2.    J. Liu, M. Tian, Lei Shen*, Surface effects on the degree of twist in amyloid fibril structures. Chem. Commun. 2020, 56, 3147.

3.    J. Liu, M. Tian, Lei Shen*, Nanopatterned polymer surface modulates twist polymorphism in a single amyloid fibril. Macro. Rapid Commun. 2020, 41, 1900619.

4.    (Invited cover work) S. Cai, J. Liu, M. Tian, K Wang, Lei Shen*, Diffusion dynamics of a single collapsed homopolymer globule at solid-liquid interface. Soft Matter, 2020, 16, 2431.

5.    S. Gong, J. Liu, M. Tian, K Wang, S. Cai, W. Wang, Lei Shen*, Unravelling the mechanism of amyloid-β peptide oligomerization and fibrillation at chiral interfaces. Chem. Commun., 2019, DOI: 10.1039/C9CC06980A.

6.    (Invited cover work) P. Li, Y. Shen, L. Wang, W. Lu, W. Li, K. Chen, Y. Zhou, Lei Shen*, F. Wei*, W. Zheng, The electric double layer structure modulates poly-dT25 conformation and adsorption kinetics at the cationic lipid bilayer interface. Soft Matter, 2019, 15, 4445-4453.

7.    J. Lin, K. Wang, X. Xia, Lei Shen*, Quantification of multivalency in protein oligomer coated nanoparticles targeting dynamic membrane glycan receptors. Langmuir, 2018, 34, 8415-8421.

8.    M. Yang, K. Wang, J. Lin, L. Wang, F. Wei*, J. Zhu, W. Zheng, Lei Shen*. Gel phase membrane retards amyloid beta-peptide (1-42) fibrillation by restricting slaved diffusion of peptides on lipid bilayers. Langmuir, 2018, 34, 8408-8414.

9.    K. Wang, Y. Chen, X. Gong, J. Xia, J. Zhao*, Lei Shen*. A mobile precursor determines protein resistance on nanostructured surfaces. Phys. Chem. Chem, Phys., 2018, 20, 12527-12534.

10.  K. Shezad, K. Zhang, M. Hussain, H. Dong, C. He, X. Gong, X. Xie, J. Zhu*, Lei Shen*. Surface roughness modulated diffusion and fibrillation of amyloid-beta peptide. Langmuir, 2016, 32, 8238-8244.

11.  Lei Shen, Y. Wang, C. Lin, H. Liu*, A. Guo*, X. Y. Zhu*. Membrane environment can enhance the interaction of glycan binding protein to cell surface glycan receptors. ACS Chem. Biol., 2014, 9, 1877-1884.

  12. Lei Shen, T. Adachi, D. Vanden Bout, X. Y. Zhu*. A mobile precursor determines amyloid-beta peptide fibril formation at interfaces. J. Am. Chem. Soc., 2012, 134, 14172-14178.
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