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徐海星

来源:3512cc新萄京官网 发布时间:2019.01.17 10:55

  

  

 

   姓名:徐海星    

  性别:    

  出生年月: 197310 

  学位:博士 

  职称:教授、系主任、硕士/博士生导师

  联系电话:13277097102     

  Emailxuhaixingwhut@163.com 

 

   徐海星,教授、博士生导师。湖北省毒理学会常务理事、湖北省中医药学会常务理事、湖北省药学会中药天然药物分会常务委员、武汉市生物医学工程学会理事、武汉市黄鹤英才、3512cc新萄京官网网址制药工程系主任、特色专业责任教授、精品课程教学名师。长期从事天然药物(中药)活性成分与制剂、药物新剂型与新技术、生物医用高分子材料等领域的研究。尤其在靶向药物智能载体和再生医学及药物缓控释的研究等方向成绩显著。主持国家自然科学基金、湖北省自然科学基金、武汉市黄鹤英才计划、湖北省中小企业自主创新基金、武汉市国际合作、武汉市中小企业自主创新基金、中央高校自主创新基金和企业合作项目数项,参与国家、省、市项目数项。发表文章50余篇,申请专利20余项,获批10余项。

教育经历:

  1993.09-1997.06 湖北中医药大学              中药学学士

  1999.09-2002.06 湖北中医药大学              中药学硕士

  2004.09-2007.12 3512cc新萄京官网网址生物中心           生物材料学博士

  工作经历:

  1997.07-1999.08 武汉华珍医药保健品有限公司

  2002年-至今   3512cc新萄京官网网址3512cc新萄京官网制药工程系

  2012.07-2013.07 美国密歇根大学访问研究

研究领域

  1、药物新剂型与新技术;

  2、中药(天然药物)活性成分与制剂;

  3、生物医用高分子材料

 

近年主持的主要科研项目

1)适于长节段周围神经再生的神经导管的研发,武汉市市委组织部黄鹤英才计划

2)具有电刺激作用的三维梯度β-TCP复合神经导管材料的研究(51572206),国家自然科学基金面上项目

3)抗卵巢癌药物苯丁酸氮芥控释靶向给药系统的构建与评价(2010CDB01006),湖北省自然科学基金

4)卵巢癌靶向给药系统的组装及其抗癌作用研究(201171034316),武汉市国际合作项目

5)壳聚糖皮肤抗菌凝胶(武财企(2011937号),武汉市中小企业自主创新基金

6)化学药三类新药克林霉素磷酸酯的研制,湖北省中小企业自主创新基金

7)小儿遗尿宁颗粒的质量标准提高研究,企业合作项目

研究成果目录

期刊论文

[1] Zhang Wanting, Liu Tingting, Wu Man, Chen Xiaochen, Han Li, Shi Zhenzhong, Li Yuying, Li Xiyang, Xu Hai-xing *, Gong Li-kun *, Xu Peihu *, Geng Yong *. Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 1. Acta Pharmacologica Sinica (2021) 0:1-9; https://doi.org/10.1038/s41401-020-00574-4.

[2] Zheng Furong, Li Rui, He Qundi, Koral Kelly, Junyan Tao, Fan Lihong, Xiang Runzhi, Ma Jingyao, Wang Na, Yin Yixia, Huang Zhijun, Xu Peihu, Xu Haixing*. The electrostimulation and scar inhibition effect of chitosan/oxidized hydroxyethyl cellulose/reduced graphene oxide/asiaticoside liposome-based hydrogel on peripheral nerve regeneration in vitro [J]. Materials Science and Engineering: C, 2020, 109:110560.

[3] Guo Xinglei, Xu Haixing*, He Qundi, Yu Yunxuan, Ming Xiaofei, Zheng Furong, Wang Xiaobin, Huang Zhijun, Zhao Meng, Xu Peihu*. Preparation and characterization of conductive poly-dl-lactic-acid/tetra-aniline conduit for peripheral nerve regeneration[J]. Journal of Bioactive and Compatible Polymers, 2019, 34(2):190-208.

[4] Bu Ying, Xu Haixing*, Li Xin, Xu Wenjin, Yin Yixia, Dai Honglian, Wang Xiaobin, Huang Zhijun, Xu Peihu. A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration[J]. RSC Advances, 2018, 8(20):10806- 10817.

[5] Guo Xinglei, Liu Gang, He Qundi, Xu Haixing*, Yu Yunxuan, Ke Changsheng, Ming Xiaofei, Zhao Meng, Wang Xiaobin, Huang Zhijun, Xu Peihu. The study of nerve conduit with biocompatibility and electrical stimulation effect, Journal of Wuhan University of Technology[J]. Materials Science Edition, 2018, 33(6):1530-1539.

[6] Zhou Huimin, Xu Haixing*, Li Xin, Lu Yahui, Ma Tian, Cai Xinjie, Li Rui, XuPeihu, Gao Yuxiang, Wang Xiaobing. Hyaluronic acid-RGD peptide conjugated mesoporous silica-coated gold nanorods for cancer dual-targeted chemo-photothermal therapy[J]. Journal of Wuhan University of Technology-Materials Science Edition, 2018, 33(2):512-523.

[7] Li Yiping, Liu Hui, Xu Haixing*, BaoYun, Yan Xiumei, Li Yixuan, Wang Xiaobing, Huang Zhijun, Xu Peihu. Preparation and characterization of a conduit for peripheral nerve regeneration[J]. Current Applied Polymer Science, 2017, 1(1):1-10.

[8] Zhou, Huimin, Xu Haixing*, Li Xin, Lv Yahui, Ma Tian, Guo Shiying, Huang Zhijun, Wang Xiaobing, Xu Peihu*. Dual targeting hyaluronic acid - RGD mesoporous silica coated gold nanorods for chemo-photothermal cancer therapy[J]. Materials Science and Engineering: C, 2017,81:261-270.

[9] Guo Yufeng, Xu Haixing*, Li Yiping, Wu Fengzheng, Li Yixuan, Bao Yun, Yan Xiumei, Huang Zhijun, Xu Peihu. Hyaluronic acid and Arg-Gly-Asp peptide modified Graphene oxide with dual receptor-targeting function for cancer therapy[J]. Journal of Biomaterials Applications, 2017, 32(1):54-65.

[10] Wu Fengzheng, Xu Haixing*, Zhu Zhihua, Li Xin, Lu Yahui, Ma Tian, Cai Xinjie, Li Rui, Wang Xiaobing, Xu Peihu. Preparation and characterization of an intelligent multi-target tracking HA-RGD-CLB-QDs drug delivery system[J]. Journal of Wuhan University of Technology-Materials Science Edition, 2017, 32(6):1493-1502.

[11] Xu Haixing, Zhang Lingxi, Bao Yun, Yan Xiumei, Yin Yixia, Li Yiping, Wang Xinyu, Huang Zhijun, Xu Peihu*. Preparation and characterization of injectable chitosan-hyaluronic acid hydrogels for nerve growth factor sustained release, Journal of Bioactive and Compatible Polymers, 2017, 32(2):146-162.

[12] Xu Haixing, Wang Zhihui, Li Yan, Guo Yufeng, Zhou Huimin, Li Yiping, Wu Fengzheng, Zhang Lingxi, Yang Xiawen, Lu Bo, Huang Zhijun, Xu Wenjin, Xu Peihu*. Preparation and characterization of a dual-receptor mesoporous silica nanoparticle-hyaluronic acid-RGD peptide targeting drug delivery system, RSC Advances, 2016, 6(46):40427-40435.

[13] Zhang Lingxi, Chen Yifan, Xu Haixing*, Bao Yun, Yan Xiumei, Li Yixuan, Li Yiping, Yin Yixia, Wang Xinyu, Qiu Tong, Huang Zhijun, Xu Peihu, Wang Xiaobing. Preparation and evaluation of an injectable chitosan-hyaluronic acid hydrogel for peripheral nerve regeneration[J]. Journal of Wuhan University of Technology-Materials Science Edition, 2016, 31(6):1401-1407.

[14] Yin Yixia, Xiao Gao, Zhang Kaiming, Ying Guoliang, Xu Haixing, De Melo Bruna A G, Li Shipu, Liu Fang, Yetisen Ali K, Jiang Nan*. Tacrolimus- and Nerve Growth Factor-Treated Allografts for Neural Tissue Regeneration[J]. ACS Chemical Neuroscience, 2019, 10(3):1411-

1419.

[15] Yang Jia, Lu Weifei, Xiao Jinling, Zong Qi, Xu Haixing, Yin Yihua, Hong Hao, Xu Wenjin*. A positron emission tomography image-guidable unimolecular micelle nanoplatform for cancer theranostic applications[J]. Acta Biomaterialia, 2018, 79:306-316.

[16] Wang Lin, Xu Haixing, Liu Zewen, Sun Taolei, Yuan Chengqing, Yang Ying, Guo Junhui, Xie Hao*. Magnetic immobilization of a quorum sensing signal hydrolase[J]. AiiA, Microbiology Open, 2019,8: e797.

[17] Huang Lin, Liu Jia, Gao Fan, Cheng Qian, Lu Bo, Zheng Hua, Xu Haixing, Xu Peihu, Zhang Xianzheng, Zeng Xuan. A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy[J]. Journal of Materials Chemistry B, 2018, 28(6):4618-4629.

[18] Wu Xiaopei, Dai Honglian, Liu Langlang, Xu Chao, Yin Yixia, Yi Jiling, Bielec Monika Dorota, Han Yingchao, Li Shipu. Citrate reduced oxidative damage in stem cells by regulating cellular redox signaling pathways and represent a potential treatment for oxidative stress-induced diseases[J]. Redox Biology, 2018, 21(101057):1-17.

专利

(1) 徐海星; 布颖; 许沛虎; 黄志军; 郭兴蕾; 张希; 马慧; 向梅; 闫秀美; 包昀. 聚吡咯 生物导电水凝胶及其制备方法和应用,授权发明专利,2017-4-24 2037-4-23, 中国, ZL201710271982.1.

(2) 徐海星; 张凌溪; 许沛虎; 郑芙蓉; 金鸣; 李安召; 汪志辉. 一种神经生长因子可注 射原位水凝胶、制备及其应用,授权发明专利, 2014-12-10 2024-12-9, 中国, ZL201410758132.0.

(3) 徐海星; 李燕; 许沛虎; 张凌溪; 李依萍; 郭兴蕾; 黄志军. 一种被可注射水凝胶包 裹的生长因子多孔微球复合系统,2015-11-30, 中国,CN201510863496.X.

(4) 徐海星; 李依萍; 许沛虎; 黄志军; 张凌溪; 李燕; 郭兴蕾; 吴峰政. 具有电刺激作 用的仿生纳米纤维支架制备方法,2016-1-15,  中国,CN201610027910.8.

(5) 徐海星; 郭兴蕾; 许沛虎; 黄志军; 马慧; 布颖; 张希; 郑芙蓉; 向梅. 具有电活性 TA#HA 复合神经导管及其制备方法,2017-3-15, 中国,CN201710153263.X.

(6) 徐海星; 郑芙蓉; 许沛虎;  黄志军;  马小慧;  向梅;  明晓飞;  余韵轩;  张婉婷;  宁偲 ; 李锐; 蔡新杰. 一种具有电刺激与抑制神经瘢痕作用的载脂质体凝胶及其制备方法, 2018-7-23,  中国,CN201810812548.4.

(7) 许沛虎; 郭玉凤; 徐海星; 黄志军; 张凌溪; 李依萍; 周汇敏; 吴峰政; 杨夏雯. HA/RGD 修饰的靶向氧化石墨烯双载药复合材料制备方法,授权发明专利,2016-6-8 2036- 6-7,  中国,ZL201610027140.7.

(8) 许沛虎; 周汇敏; 徐海星; 黄志军; 张凌溪; 郭玉凤; 李依萍; 吴峰政; 杨夏雯.  纳米复合靶向给药系统制备方法,2016-1-15,  中国,CN201610027271.5.

(9) 许沛虎; 吴峰政; 徐海星 ; 黄志军; 李依萍; 李燕; 周汇敏; 郭玉凤; 郭兴蕾. HA/RGD 双受体介导多靶点给药系统的制备方法,授权发明专利,2016-6-22 2036-6-22, 中国,ZL201610030607.3.

(10) 许沛虎; 马慧; 徐海星; 黄志军; 周汇敏; 郭玉凤; 吴峰政; 布颖; 张希; 郭兴蕾. 双功能介孔 硅球复 靶向给药系 统的制 方法, 2017-3-22 2027-3-21, 中国, ZL201611094868.8.

(11) 许沛虎; 张希; 徐海星; 黄志军; 马慧; 郭兴蕾; 布颖; 梁鹏; 李意璇. 多功能协同 主动靶向给药系统及其制备和应用,2017-3-31, 中国,CN201710205507.4.

(12) 许沛虎; 马小慧; 徐海星; 黄志军; 郑芙蓉; 向梅; 赵梦; 刘梦婕; 董杰鹏; 宁偲偲; 张婉婷. 一种近红外光聚合可注射水凝胶的制备与应用,2018-7-24, 中国, CN201810821548.0.

(13) 徐海星; 李锐; 许沛虎; 黄志军; 宁偲偲; 张婉婷; 闫秀美; 马毓聪; 李意璇; 李信. 一种具有电刺激和促血管生成作用的神经修复载药系统的制备方法,2019-12-18, 中国, CN201911312595.3.

 

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